FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis
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چکیده
منابع مشابه
FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.
Fibroblast growth factors (FGFs) are signals from the apical ectodermal ridge (AER) that are essential for limb pattern formation along the proximodistal (PD) axis. However, how patterning along the PD axis is regulated by AER-FGF signals remains controversial. To further explore the molecular mechanism of FGF functions during limb development, we conditionally inactivated fgf receptor 2 (Fgfr2...
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ژورنال
عنوان ژورنال: Development
سال: 2008
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.013268